Amyloid Beta Protein

Amyloid

DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Fundamental description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present inside the vascular amyloid deposits. Aβ40 accommodates of C-terminal membrane insertion space. It reveals structural transition from random coil to a α-helical building in a water-micelle medium.

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the foremost constituents of senile plaques and neurofibrillary tangles that occur inside the hippocampus, neocortex, and amygdala of victims with Alzheimer′s sickness.
Amyloid β Protein Fragment 1-40 (Aβ40) varieties cation primarily based ion channels.

Utility

Amyloid β Protein Fragment 1-40 has been used:

  • inside the temperature primarily based conformational analysis using Fourier rework infrared/differential scanning calorimetry (FT-IR/DSC) analysis
  • as a reference commonplace in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of victims with head trauma
  • as a ingredient of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

Reconstitution

For maximal natural train, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.

Totally different Notes

Lyophilized from 0.1% TFA in H2O
Amyloid
Amyloid

Abstract

Alzheimer’s sickness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For just a few years, investigators have been puzzled by the weak to nonexistent correlation between the amount of neuritic plaque pathology inside the human thoughts and the diploma of scientific dementia. Present advances in our understanding of the occasion of amyloid pathology have helped treatment this thriller. Substantial proof now signifies that the solubility of Aβ, and the quantity of Aβ in quite a few swimming swimming pools, may be further rigorously related to sickness state. The composition of these swimming swimming pools of Aβ shows utterly totally different populations of amyloid deposits, and has explicit correlates with the scientific standing of the affected particular person.

 

Imaging utilized sciences, along with new amyloid imaging brokers based mostly totally on the chemical building of histologic dyes, in the intervening time are making it doable to hint amyloid pathology along with sickness growth inside the residing affected particular person. Curiously, these approaches level out that the Aβ deposited in AD is totally totally different from that current in animal fashions. Principally, deposited Aβ is further merely cleared from the thoughts in animal fashions, and does not current the equivalent bodily and biochemical traits as a result of the amyloid current in AD. This raises needed factors regarding the occasion and testing of future therapeutic brokers.

Key phrases: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril

beta Amyloid 40 protein

30R-3013 500 ug
EUR 392.4
Description: Purified recombinant beta Amyloid 40 protein

beta Amyloid 42 protein

30R-3014 500 ug
EUR 392.4
Description: Purified recombinant beta Amyloid 42 protein

[Lys15]-Amyloid beta Protein (15-21)

20-abx265888
  • EUR 427.20
  • EUR 644.40
  • EUR 343.20
  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta Protein (25-35) amide

20-abx266281
  • EUR 594.00
  • EUR 978.00
  • EUR 427.20
  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta (A4) Precursor Protein

20-abx260881
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Amyloid Beta (A4) Precursor Protein

PR27172 10 ug
EUR 381.6

Amyloid Beta A4 Protein (APP) Antibody

20-abx137437
  • EUR 844.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 20 ug
  • 5 ug

Amyloid Beta A4 Protein (APP) Antibody

20-abx210155
  • EUR 526.80
  • EUR 393.60
  • 100 ug
  • 50 ug

Amyloid Beta A4 Protein (APP) Antibody

abx230512-100ug 100 ug
EUR 577.2

Amyloid Beta A4 Protein (APP) Antibody

abx230513-100ug 100 ug
EUR 577.2

Amyloid Beta A4 Protein (APP) Antibody

abx224105-100ug 100 ug
EUR 493.2

Amyloid Beta A4 Protein (APP) Antibody

abx146535-100ug 100 ug
EUR 526.8

Amyloid Beta A4 Protein (APP) Antibody

abx146606-100ug 100 ug
EUR 526.8

Amyloid Beta A4 Protein (APP) Antibody

abx412477-01mg 0.1 mg
EUR 644.4

Amyloid Beta A4 Protein (APP) Antibody

abx412509-01ml 0.1 ml
EUR 844.8

Amyloid Beta A4 Protein (APP) Antibody

abx412510-01ml 0.1 ml
EUR 844.8

Amyloid Beta A4 Protein (APP) Antibody

abx027538-400ul 400 ul
EUR 627.6

Amyloid Beta A4 Protein (APP) Antibody

abx027538-80l 80 µl
EUR 343.2

Amyloid Beta A4 Protein (APP) Antibody

abx032791-400ul 400 ul
EUR 627.6

Amyloid Beta A4 Protein (APP) Antibody

abx032791-80l 80 µl
EUR 343.2

Amyloid Beta A4 Protein (APP) Antibody

abx032792-400ul 400 ul
EUR 627.6

Amyloid Beta A4 Protein (APP) Antibody

abx032792-80l 80 µl
EUR 343.2

Amyloid Beta A4 Protein (APP) Antibody

abx125413-50ul 50 ul
EUR 493.2

Amyloid Beta A4 Protein (APP) Antibody

20-abx125527
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Amyloid Beta A4 Protein (APP) Antibody

20-abx002265
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Amyloid Beta A4 Protein (APP) Antibody

20-abx000594
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Amyloid beta Precusor Protein Antibody

F51499-0.4ML 0.4 ml
EUR 322.15
Description: APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

Human amyloid beta A4 protein ELISA Kit

CSB-E14352h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human amyloid beta A4 protein in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human amyloid beta A4 protein ELISA Kit

1-CSB-E14352h
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human amyloid beta A4 protein in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Amyloid beta A4 protein Polyclonal Antibody

42478-100ul 100ul
EUR 399.6

Amyloid beta A4 protein APolyclonal Antibody

42069-100ul 100ul
EUR 399.6

Amyloid Beta A4 Protein (APP) Antibody Pair

abx117507-1pair5x96wellplates 1 pair (5x96 well plates)
EUR 1212

Amyloid beta / A4 Protein Precursor770 (667-676)

20-abx266155
  • EUR 526.80
  • EUR 794.40
  • EUR 393.60
  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta/A4 Protein Precursor770 (667-676)

5-00669 4 x 5mg Ask for price

Amyloid beta/A4 Protein Precursor770 (740-770)

5-00670 4 x 1mg Ask for price

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