Amyloid Beta Protein

Amyloid

DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Fundamental description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present inside the vascular amyloid deposits. Aβ40 accommodates of C-terminal membrane insertion space. It reveals structural transition from random coil to a α-helical building in a water-micelle medium.

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the foremost constituents of senile plaques and neurofibrillary tangles that occur inside the hippocampus, neocortex, and amygdala of victims with Alzheimer′s sickness.
Amyloid β Protein Fragment 1-40 (Aβ40) varieties cation primarily based ion channels.

Utility

Amyloid β Protein Fragment 1-40 has been used:

  • inside the temperature primarily based conformational analysis using Fourier rework infrared/differential scanning calorimetry (FT-IR/DSC) analysis
  • as a reference commonplace in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of victims with head trauma
  • as a ingredient of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

Reconstitution

For maximal natural train, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.

Totally different Notes

Lyophilized from 0.1% TFA in H2O
Amyloid
Amyloid

Abstract

Alzheimer’s sickness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For just a few years, investigators have been puzzled by the weak to nonexistent correlation between the amount of neuritic plaque pathology inside the human thoughts and the diploma of scientific dementia. Present advances in our understanding of the occasion of amyloid pathology have helped treatment this thriller. Substantial proof now signifies that the solubility of Aβ, and the quantity of Aβ in quite a few swimming swimming pools, may be further rigorously related to sickness state. The composition of these swimming swimming pools of Aβ shows utterly totally different populations of amyloid deposits, and has explicit correlates with the scientific standing of the affected particular person.

 

Imaging utilized sciences, along with new amyloid imaging brokers based mostly totally on the chemical building of histologic dyes, in the intervening time are making it doable to hint amyloid pathology along with sickness growth inside the residing affected particular person. Curiously, these approaches level out that the Aβ deposited in AD is totally totally different from that current in animal fashions. Principally, deposited Aβ is further merely cleared from the thoughts in animal fashions, and does not current the equivalent bodily and biochemical traits as a result of the amyloid current in AD. This raises needed factors regarding the occasion and testing of future therapeutic brokers.

Key phrases: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril

beta Amyloid 42 protein

30R-3014 500 ug
EUR 392.4
Description: Purified recombinant beta Amyloid 42 protein

beta Amyloid antibody

70R-10624 1 ml
EUR 831.6
Description: Affinity purified Chicken polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-12571 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

Beta Amyloid antibody

70R-51450 100 ul
EUR 344.4
Description: Purified Polyclonal Beta Amyloid antibody

beta Amyloid Antibody

35506-100ul 100ul
EUR 468

beta Amyloid antibody

20R-AR011 250 ul
EUR 457.2
Description: Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

10R-7917 100 ug
EUR 386.4
Description: Mouse monoclonal beta Amyloid antibody

beta Amyloid antibody

10R-A124a 50 ug
EUR 1213.2
Description: Mouse monoclonal beta Amyloid antibody

beta-Amyloid antibody

22965-100ul 100ul
EUR 468

beta Amyloid antibody

70R-AR020 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-BR019 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

Amyloid beta-Protein (1-43)

5-00662 4 x 1mg Ask for price

Amyloid beta-Protein (20-29)

5-00663 4 x 5mg Ask for price

Amyloid beta-Protein (29-40)

5-00665 4 x 1mg Ask for price

Amyloid beta-Protein (33-42)

5-00666 4 x 5mg Ask for price

Amyloid beta-Protein (42-1)

5-00667 4 x 1mg Ask for price

Amyloid beta-Protein (6-20)

5-00668 4 x 1mg Ask for price

Amyloid beta 1-42 Protein

abx060277-100ug 100 ug
EUR 910.8

Amyloid beta Protein (20-29)

20-abx266170
  • EUR 526.80
  • EUR 861.60
  • EUR 393.60
  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta Protein (33-42)

20-abx266417
  • EUR 644.40
  • EUR 1078.80
  • EUR 460.80
  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta (A4) Precursor Protein

20-abx260881
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Amyloid Beta (A4) Precursor Protein

PR27172 10 ug
EUR 381.6

Amyloid beta 40 antibody

10R-8435 100 ul
EUR 471.6
Description: Mouse monoclonal Amyloid beta 40 antibody

Beta-Amyloid (1-11)

A1002-1 1 mg
EUR 122.4
Description: Beta-amyloid (1-11) (Abeta or A?) (C56H76N16O22) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.

Beta-Amyloid (1-11)

A1002-10 10 mg
EUR 373.2
Description: Beta-amyloid (1-11) (Abeta or A?) (C56H76N16O22) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.

Beta-Amyloid (1-11)

A1002-25 25 mg
EUR 498
Description: Beta-amyloid (1-11) (Abeta or A?) (C56H76N16O22) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.

Beta-Amyloid (1-11)

A1002-5 5 mg
EUR 247.2
Description: Beta-amyloid (1-11) (Abeta or A?) (C56H76N16O22) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.

Amyloid beta A4 antibody

70R-30561 100 ug
EUR 392.4
Description: Rabbit polyclonal Amyloid beta A4 antibody

beta-Amyloid (1-11)

5-00416 4 x 5mg Ask for price

beta-Amyloid (1-15)

5-00418 4 x 5mg Ask for price

beta- Amyloid (1-16)

5-00419 4 x 1mg Ask for price

beta-Amyloid (1-28)

5-00421 4 x 1mg Ask for price

beta- Amyloid (1-33)

5-00422 4 x 1mg Ask for price

beta- Amyloid (1-34)

5-00423 4 x 1mg Ask for price

beta- Amyloid (1-37)

5-00424 4 x 1mg Ask for price

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